The BTRI is a new initiative of the Department of Science and Technology initiated by the CSIR and the University of Cape Town (UCT) in the translation of biomedical research. The initiative aims to bring scientists from a number of institutions to work in close proximity with each other in a biomedical research environment, with access to an academic hospital and medical school to support translational research. The flagship project of the BTRI is a Precision Medicine project supported by the Medical Research Council of South Africa. It makes use of several advanced cutting edge molecular diagnostic, imaging tools, systems & synthetic biology tools to permit highly precise cancer diagnostics, matching tumor to appropriate drug regimens. In the future this will lead to gene-based therapies, treatments, diagnostics, training, education, and lead to job creation for scientists in South Africa.